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Description

hydrocodone 10 mg

hydrocodone 10 mg is an opioid analgesic and antitussive and occurs as fine, white crystals or as a crystalline powder. It is affected by light. The chemical
name is: 4,5 α-epoxy-3-methoxy-17-methylmorphinan6-one tartrate hydrate.

Hydrocodone Bitartrate (hydrocodone 10 mg)

Class: Opiate Agonists
ATC Class: R05DA03
VA Class: RE301
CAS Number: 34195-34-1
Brands: Hysingla ER, Zohydro ER

Classification hydrocodone 10 mg

Therapeutic:allergy, cold, and cough remedies (antitussive), opioid analgesics
Pharmacologic: opioid agonists/nonopioid analgesic combinations Schedule II (Zohydro ER)III (in combination)

Pregnancy Category C

For information on the acetaminophen and ibuprofen components of these formulations, see the acetaminophen and ibuprofen monographs.

Indications

Extended-release product: Management of pain that is severe enough to warrant daily, around-the-clock , long-term opioid treatment where alternative treatment options are inadequate. Combination products: Management of moderate to severe pain. Antitussive (usually in combination products with decongestants).

Action hydrocodone 10 mg

Bind to opiate receptors in the CNS. Alter the perception of and response to painful stimuli while producing generalized CNS depression: Suppress the cough reflex via a direct central action. Therapeutic Effects: Decrease in severity of moderate pain. Suppression of the cough reflex.

Pharmacokinetics

Absorption:Well absorbed following oral administration.
Distribution: Unknown. Metabolism and Excretion: Mostly metabolized by the liver; eliminated in the urine (50– 60% as metabolites, 15% as unchanged drug).

Route/Dosage hydrocodone 10 mg

PO (Adults): Analgesic—2.5– 10 mg q 3– 6 hr as needed; if using combination
products, acetaminophen dosage should not exceed 4 g/day and should not exceed 5 tablets/day of ibuprofen-containing products; Antitussive—5 mg q 4– 6 hr as needed; Extended release—10 mg q 12 hr; mayqas needed in increments of 10 mg q 12 hr q 3– 7 days.

PO (Children): Analgesic (1– 13 yr)—0.1– 0.2 mg/kg q 3– 4 hr. Antitussive —
0.6 mg/kg/day divided q 6– 8 hr; (maximum doses 2 yr: 1.25 mg/dose; 2– 12 yr: 5 mg/dose; 12 yr: 10 mg/dose) .

Adults

Analgesic hydrocodone dosages should be determined based on pain severity and patient response/ tolerance. In individuals with severe pain or those who have become tolerant to the analgesic effects of hydrocodone, it may be necessary to exceed the usual dosage. Reduced hydrocodone dosages are
indicated in high-risk patients and the elderly. The maximum daily dosage for the acetaminophen/ hydrocodone combination is restricted by the maximum acetaminophen dose of 4 g daily to limit the risk of hepatic damage and severe hypersensitivity reactions associated with acetaminophen use.

Adverse Reactions/Side Effects

Noted for hydrocodone only; see acetaminophen/ibuprofen monographs for specific information on individual components CNS: confusion, dizziness, sedation, euphoria, hallucinations, headache, unusual dreams.EENT: blurred vision, diplopia,miosis. Resp: respiratory depression. CV: hypotension, bradycardia. GI:constipation, dyspepsia, nausea, vomiting. GU: urinary retention. Derm: sweating. Misc: physical dependence, psychological dependence, tolerance.

PRECAUTIONS

General :

Special Risk Patients: As with any narcotic analgesic agent, hydrocodone 10 mg Tablets should be used with caution in elderly or debilitated patients and those with
severe impairment of hepatic or renal function, hypothyroidism, Addison’s disease, prostatic hypertrophy or urethral stricture. The usual precautions should be observed and the possibility of respiratory depression should be kept in mind. Cough Reflex: Hydrocodone suppresses the cough
reflex; as with all narcotics, caution should be exercised when hydrocodone 10 mgTablets are used postoperatively and in patients with pulmonary disease.

Information for Patients:

hydrocodone 10 mg, like all narcotics, may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery; patients should be cautioned accordingly. Alcohol and other CNS depressants may produce an additive CNS depression, when taken with this combination product, and should be avoided. hydrocodone 10 mg may be habit forming. Patients should take the drug only for as long as it is prescribed, in the amounts prescribed, and no more frequently than prescribed

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